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Novel Dosage Forms & Drug Delivery System

Drug delivery is the method of administering pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery is a concept heavily integrated with dosage form and route of administration. The drug delivery system can be divided into two main types: Conventional and Novel drug delivery systems. Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety and efficacy. Conventional dosage forms provide drug release immediately and it causes fluctuation of drug level in blood depending upon dosage form.

  • What are the Novel dosage forms and New drug delivery system?

Novel dosage forms are relatively new on the market or use new and/or unique delivery systems, or use unique delivery systems or unique devices before, during, or after administration. New drug delivery system (NDDS) development is largely based on promoting the therapeutic effects of a drug and minimizing its toxic effects by increasing the amount and persistence of a drug in the vicinity of a target cell and reducing the drug exposure of non-target cells, it is often approached via a drug’s chemical formulation, but it may also involve medical devices or drug-device combination products. Novel pharmaceutical dosage forms cover a broad range of formulation delivery platforms such as tablets, capsules, cachets, sustained release dosage forms, parenteral dosage forms, transdermal dosage forms, metered dose inhalants, solutions, emulsions, and suspension. 

Classification Of NDDS With Reference To Release Control

  1. Matrix Diffusion Types:
  • Rigid Matrix Diffusion.
  • Swellable Matrix Diffusion.
  • Reservoir System.

2. Dissolution Matrix Type:

  • Encapsulation.

3. Dissolution & Diffusion Controlled Release System.

4. Water penetration/Osmotic Pressure Controlled NDDS.

5. Chemically Controlled NDDS.

6. Hydrogels.

7. Ion Exchange Resins Controlled Release Systems.

Modes Of NDDS

  • Targeted Drug Delivery System, e.g. Colon targeted drugs.
  • Controlled Drug Delivery System, e.g. Nifidipine. 
  • Modulated Drug Delivery System, e.g. Metered dose inhaler drugs.

Novel Carriers For NDDS

Benefits Of NDDS:

New drug delivery systems can provide improved or unique clinical benefits, such as:

  • Improvement of the patient’s compliance.
  • Improved outcomes.
  • Reduction of adverse effects.
  • Improvement of the patient’s acceptance of the treatment.
  • Avoidance of costly interventions such as laboratory services.
  • Allowing the patients to receive medication as outpatients.
  • Possibly a reduction in the overall use of medicinal resources. 

Examples Of Delivery Novel Dosage Forms (DNDFs)

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